THE RELATION BETWEEN HELICOBACTER PYLORI INFECTION AND GASCTRIC MUCOSAL DAMAGES

Introduction and aim: Chronic gastritis is the most common manifestation of Helicobacter pylori infection. The changes in the gastric mucosa have tendency to progress to mucosal atrophy. By this work we want to prove the relation between Helicobater pylori infection and inflamatory changes of gastric mucosa, the grade of change according to the type of gastritis and the possible relation of Helicobacter Pylori infection to age and gender. Material and methods: In this retrospective study, by period of time 2010-2013, are taken to study 200 individuals, who submitted at a private hospital center, with gastro-intestinal symptoms, vomiting, pain or upper abdominal discomfort, bloody vomiting and black coloured stool. To diagnose the inflamatory changes of gastric mucosa and the presence of Helicobacter pylori, it is used the invasive method of endoscopy. The zones where biopsies are taken are cardia, antrum, corpus, fundus and pylorus. The taken biopsy is stained by Giemsa stain method, modified. Age and gender are taken for each patient. According to the degree of changes found in submucosal glands, the sample is devided in three individual groups: without gastritis, non-specific gastritis and chronic gastritis. In the examined group there are positive and negative status of Helicobacter pylori infection. Results: Acoording to the our study, Helicobacter pylori results to be the main cause of chronic gastritis development (χ2 = 64.45; p<0.0005). Percentage positivity of Helicobacter pylori in individuals with gastritis is 75,5%. There couldn’t be fined an statistically reliable connection between Helicobacter pylori and the samples individuals gender. (χ2 = 4.3; p=0.364).