SYNTHESIS OF 2, 5- DISUBSTITUTED-1, 3, 4- THIADIAZOLE DERIVATIVES AND EVALUATION OF THEIR ANTIBACTERIAL ACTIVITY

In this work 2, 5- dimarcapto-1, 3, 4-thiadiazole[1] was synthesized from the reaction of hydrazine hydrate with carbon disulfide and then was converted into the hydrazino derivative [2], Reaction of compound [2] with pheny isocyanate, phenyliso thiocyanate, 4-chloro phenyliso thiocyanate leads to formation compounds[3-5] On otherhand treatment of compounds [1] with thiosemicarbazide gave compound[6], which upon refluxing with o ethyl chloro formate in dry benzene yielded derivative [11]. Moreover, Schiff Bases derivatives [7-10] have been synthesized by treatment of compound([2, 6]with various aromatic aldehyde New synthesized compounds were characterized by their melting points, FT-IR and (1HNMR, 13C-NMR of some of them) spectra. The biological activity evaluated of the final products showed that some of these compounds possess good antibacterial activity.