IMPROVEMENT OF CERVICAL EPITHELIUM REPAIR AND PREVENTION OF COMPLICATIONS AFTER ELECTROSURGICAL TREATMENT

The problem of optimization the man-agement of women with cervical pathology after destruc-tive methods of treatment is actual because of its high fre-quency. We used vaginal suppositories "Giaval" after loop electroexcision of the cervix to prevent complications and recurrences, accelerate the regeneration of the cervical ep-ithelium, prevention of infectious complications.Aim.Study of the clinical effectiveness of the drug with hyaluronic acid to improve reparative processes in the cervical mucosa in the postoperative period.Materials and methods.The object for the pro-spective research of the clinical effect of the drug with hy-aluronic acid "Giaval" were 50 women who underwent loop FOTEK E81MV loop electroexcision of the cervix with the presence of CIN I and CIN II according to cyto-morphological examination and colposcopy and the pres-ence of LSIL after histological examination. The work was carried out on the clinical basis of the Department of Ob-stetrics and Gynecology named after I.D. Lanovoho IFNMU. According to the principle of simple randomiza-tion, patients were divided into two equal clinical groups, depending on the prescribed treatment. The main (first) clinical group (n = 25) included patients who from 7 days after electroexcision were prescribed vaginal suppositories "Giaval" for 1 suppository in the vagina at night for 15 days. In the control (second) group, women received Methyluracil suppository twice a day for 10 days. The con-trol examination, bacterioscopic, cytological examination and extended colposcopy were performed 6 weeks after treatment and then once every 3 months during the year. During the analysis of the effectiveness of treatment, the results of cervical epithelialization were evaluated 522(22)квітень-червень,2022ISSN2521-1455 (Print)ISSN2523-4250 (Online) «Art of Medicine»according to the following criteria: full effect, absent or incomplete effect, recurrence.Variational and statistical processing of research results were performed using the programs SPSS Statistics 22 and StatSoft Statistica.Results.During examination patients of both groups, no significant difference in the anamnesis or ob-jective data werefound. In the patients of the first group already on the third day using of vaginal suppositories "Giaval" there was a sharp decrease in vaginal discharge in contrast to the control group, where the discharge was intensive and continued for about a week. Lower ab-dominal pain bothered 3 (12%) women in the control group. Six weeks after PEE in the main clinical group, complete epithelialization was observed in 23 women (92%) who received postoperative treatment with Giaval. At the same time, in patients of the control group complete epithelialization was observed in only 17 women (68%), in the rest incomplete epithelialization was observed on the background of inflammatory smear type. The period of complete repair of postoperative wound defects of the cervix was 39.3 ± 1.8 and 47.4 ± 2.3 days, respectively in patients of the first and second groups.Six months after treatment all women in the main group had normal colposcopy and cytology. Abnormal colposcopy and cytology after treatment, which was con-sidered arelapse, was diagnosed in 2 (8%) patients of the second group. Cervical stenosis was also diagnosed in 6 (24%) patients in the same group.Conclusions. Using of vaginal suppositories "Giaval" improves the repair of the epithelium of the cer-vical mucosa, reduces the duration of vaginal discharge, normalizes the biocenosis of the vagina, which increases the effectiveness of treatment and reduces the frequency of postoperative complications, improve women's quality of life. The use of "Giaval" suppositories are safe and com-fortable for women as it has no side effects.