THE ROLE OF PROBIOTICS IN THE TREATMENT OF INTESTINAL DYSBIOSIS IN PATIENTS WITH LAMBLIOSIS AND ASCARIDOSIS

Parasitic diseases remain an important problem today. Recently, many cases of combined inva-sion have been registered. Mixed invasion by Giardia and roundworms is the most common in Ukraine. The clinical picture of the disease is characterized by damage to vari-ous organs and systems, but most often in patients the manifestations relate to the primary site of parasitism of pathogens -the gastrointestinal tract, which is often ac-companied by disruption of the intestinal microflora. The aim was to study the effect of probiotics containing bicar-bonate saccharomycetes in the complex therapy of patients with giardiasis, ascariasis, and combined invasion. We ex-amined 90 patients with giardiasis, ascariasis, and com-bined invasion, divided into 3 groups, depending onthe type of invasion, each of which is divided into two sub-groups, depending on the treatment (basic treatment and with the addition of probiotics). It was administered orally 1 capsule 2 times a day for 14 days. 1 capsule contains 250 mg of saccharomycetes and excipients. The control group consisted of 20 healthy individuals. The state of the intes-tinal microflora was determined using a classical microbi-ological study of feces to determine the population level of the microflora according to VA Znamensky. The research was performed twice: before treatment and 14 days after treatment. The diagnosis of giardiasis and ascariasis was confirmed by detection of the pathogen in the feces by par-asitoscopy of feces. When studying the state of the intesti-nal microflora, it was found that all patients had the fol-lowing changes before treatment. The content of bifidobacteria, lactobacilli, enterococci and the total con-tent of E. coli was reduced. At the same time, there was an increase in the content of peptococci, bacteroids, Esche-richia coli with weakly enzymatic properties, haemolytic Escherichia coli, fungi of the genus Candida and staphylo-cocci. After the basic treatment, some positive changes were observed in all groups of patients, but the content of autochthonousflora still decreased, the presence of patho-genic bacteria (staphylococci) and fungal flora was noted. The content of bifidobacteria was slightly reduced. The quantitative composition of lactobacilli was higher than 91ISSN2521-1455 (Print)ISSN2523-4250 (Online) 2(22) квітень-червень2022«Art of Medicine»before treatment. Patients had a reduced amount of bacter-oids, total Escherichia coli, although its content was higher than before treatment. An elevated level of Escherichia coli with weak enzymatic properties was noted. Hemolytic Escherichia coli was present, as well as the number of en-terococci. Fungi of the genus Candida were available also. In the 3b group of patients there were more significant signs of improvement in the microflora. After the inclusion in the treatment complex of probiotics containing saccharomycetes of billard, accord-ing to the results of bacteriological research, there was a significant positive dynamic of the intestinal microflora. The content of bifidobacteria was significantly higher compared to the other two groups. The quantitative com-position of lactobacilli was slightly reduced. The amount of bacteroids was normalized. The total content of Esche-richia coli increased, there was a decrease in the content of Escherichia coli with weak enzymatic properties. In addi-tion, the presence of haemolytic Escherichia coli was de-tected in only one patient. Almost complete normalization of the level of enterococci was observed. From the fungal flora, the level of fungi of the genus Candida was minimal, comparing similar results of other groups.