Eco-friendly, Rapid Synthesis of Some 4-Hydroxybenzoic Acid Hydrazide Derivatives

In this study, some azomethine compounds were prepared from 4-hydroxybenzoic acid hydrazide with some primary amine derivatives in different ways from the usual methods. The method used in research is utilizing water as solvent instead of any other organic solvent. In addition, lab-made microwave was used instead of hot plate or reflux method. P-hydroxy ethyl benzoate was treated directly with hydrazine hydrate in microwave oven which gave hydrazide derivative in a very short time; hydrazide derivative (1) was reacted with some carbonyl compounds (aldehyde derivatives) to produce of some Schiff base derivatives (compounds 2-14). None of these azomethine derivatives exceeded 10 minutes in lab-made micro wave and using water as solvent. Compounds (2-14) were treated with acetic anhydride in microwave oven to synthesized of some 1,3,4-oxadiazole derivatives (15-23). All compounds high yield, short time, low cost in comparison with traditionally methods. The prepared compounds were characterized by melting points, 1H-NMR, and FT-IR.