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ANALYSIS OF CORRELATION OF STROMAL CD10 EXPRESSION INCARCINOMABREASTNOSTYPEWITH HER2/NEU

Journal: International Journal of Advanced Research (Vol.10, No. 07)

Publication Date:

Authors : ; ;

Page : 212-217

Keywords : Breastcarcinoma NOS Type Prognosticmarker Stromal CD10 Stromalmarker;

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Abstract

Background:Breastcancerisoneofthemostcommoncanceramongwomen.Stromaplaysanimportantpathogeneticroleincarcinomaofbreast.Stromalmarkercouldbeusedforassessingtheprognosisofbreastcancer. Methods:30invasiveductalcarcinomaofbreastNOStypewereselected.Hematoxylinandeosinstainingwasdone.ImmunohistochemistrywasdonewithCD10,andHER2.CD10expressioninstromawasstudiedandstatisticallyanalyzedwithHER2. Results:strongpositivityforstromalCD10wasobservedin46%(14outof30)ofcases.10outof14(71%)CD10positivecasesshowedHER2/neu positivity.CD10expressionwassignificantlyassociatedHER2/neupositivity. Conclusions:StromalCD10expressionisdirectly correlatedwithHER2receptorpositivity.CD10couldbeusedasnew prognosticmarkerincarcinomaofbreast.

Last modified: 2022-08-09 21:29:40