Design and Development of Co Crystals of Paracetamol and Mefenamic Acid and its Characterization

Paracetamol is a class III drug which has limited permeability and High solubility, Mefenamic acid is a class II drug which has High permeability and Low solubility, for overcome this problems co crystallization method is used. Co crystallization is the process to enhance the physical properties of drug molecule especially the solubility. Paracetamol is analgesic and mefenamic acid belongs to anti inflammatory drug NSAID . Category they are combined for use in tablet formulation. Co crystallization was used to combine two drugs in single solid phase and thus to achieve new approach for combination therapy. Using the new approach co crystals of mefenamic acid with Paracetamol was prepared. Co crystallization of two drugs was carried out by using solvent evaporation and solution co crystallization method. The saturation solubility was done to evaluate the solubility of co crystals. Dissolution properties were determined and compared with the marketed tablet formulation. The prepared co crystals have shown several times faster release than marketed tablet and optimized co crystals were characterized by using FTIR, Dissolution study. Ketan Tamhane | Gauri Tamboli | Sayali Wagh | Supriya Khatal | Tejaswini Kande | Naziya Sayyad "Design and Development of Co-Crystals of Paracetamol and Mefenamic Acid and its Characterization" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-6 | Issue-4 , June 2022, URL: https://www.ijtsrd.com/papers/ijtsrd50154.pdf Paper URL: https://www.ijtsrd.com/pharmacy/medicinal-chemistry/50154/design-and-development-of-cocrystals-of-paracetamol-and-mefenamic-acid-and-its-characterization/ketan-tamhane