Anti Pyretic Activity of Linga Mathirai (Mercuric Sulphide Preparation) in Experimental Animals

The present pharmacological investigation was undertaken to study the anti-pyretic activity of Linga mathirai Siddha sastric Herbo mineral formulations in albino rats against yeast induced pyrexia. Five groups of six animals were used for the experiment. The yeast induced pyrexia method was standardized first by injecting 12.5% yeast suspension (s. c) followed by recording the rectal temperature at every hour of intervals. Then the evaluation of anti-pyretic activity of Siddha sastric Herbo mineral formulations was carried out by using this standard procedure. Both the samples including vehicle significantly attenuated the raise in temperature after three hours of yeast injection. The data generated during all stages of study showed that the test drug Linga mathirai (5.85 mg/kg per day) exert highly significant (P?0.001) decrease in temperature after 1 hr of administration except which was non-significant after 1 hr. The test drug Linga mathirai with high dose (58.5 mg/kg) was found to be significant (P?0.05) even after 3 hrs in comparison to standard drug (Paracetamol). The results of present study show the importance of mercury in intensifying the therapeutic efficacy of a formulation.