Surveying the Synthesis of 2H-benzo[b][1,4]oxazin-3(4H)-ones and Related Analogs
Journal: International Journal of Science and Research (IJSR) (Vol.11, No. 5)Publication Date: 2022-05-05
Authors : Rajitha Bollu; Rajasheker Reddy Eragari;
Page : 427-432
Keywords : Synthetic strategies; reactions; heterocycles;
Abstract
This review presents a systematic and comprehensive survey of the methods of preparation of 2H-benzo[b][1,4]oxazin-3(4H)-one derivatives. Many research groups have synthesized and evaluated benzoxazinones against several biological agents. This review examines recent publications relating to the synthesis of benzoxazinones. Benzoxazinone derivatives have exhibited a broad spectrum of biological activities, and approved benzoxazinone containing drugs include Bisoxatin (laxative), Caroxazone SB-64,915 (antagonist), Paraxazone (antidepressant) and DIMBOA (antibiotic). Due to their selective transformations with different reagents they have been attracting increasing attention in view of their high reactivity as building blocks for the preparation of compounds of various classes towards biological and therapeutical perspective.
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