Clinical Profile and Outcome after Thrombolysis of Prosthetic Valve Thrombosis

Background: the study was conducted to evaluate clinical profile and outcome after thrombolysis of prosthetic valve thrombosis. Methods: This was a prospective, observational, single-centre study carried out between January 2021 and December 2021 at a tertiary care centre in central India. Total 25 patients with history of symptoms related to PHVT were included in the study. Patients underwent thrombolysis as per clinical presentation. The demographic profile, clinical parameters and in hospital outcome were analysed. Results: Mean age of the patients was 42.3?14.1 years. Most of the patients presented with NYHA class III and IV (100%) symptoms. Of the total 25 patients studied 16 (64%) were poorly compliant with anticoagulants. All were thrombolysed with streptokinase. Mortality was found to be of 8 %. Embolism occurred in 24 % and major bleeding in 8 %. Conclusions: Majority of patients with prosthetic valve thrombosis presented with a subtherapeutic INR value, poor compliance and poor monitoring mainly in patients belonging to the lower socioeconomic group. Thrombolysis can be a useful option in the management of prosthetic valve thrombosis patients in a less resourceful country