Calcific Uremic Arteriolopathy (Calciphylaxis) Dermatological Case

Introduction: Calciphylaxis, also known as calcific uraemic arteriolopathy (CUA), is a rare condition characterized by exquisitely painful necrotic ulcerations in patients with end-stage renal disease (ESRD) undergoing dialysis. Calcific uraemic arteriolopathy can be characterized by obstructive vasculopathy, with calcification of small arteries and arterioles resulting in luminal occlusion and subsequently cutaneous necrosis [1]. The incidence of CUA is estimated to be approximately 1% in patients with CKD and 4% in patients on dialysis [2]. The disease is rare but devastating, increasing in dialysis population [3] and its aetiology is still unmasked that is challenging demonstrates a challenge for different specialities. Even if diagnosed in early stages, the mortality rate remains exceptionally High and the success in healing is low. [4] Mortality rates are estimated at 60-80% [5]Furthermore, the disease is characterized by skin ulceration that undergo necrosis leading to intense pain and can be localized on any part of the skin. Objective: To raise awareness of Calciphylaxis in hopes of prompting earlier recognition with improved clinical outcomes. It is a rare complication but a fatal event of chronic kidney disease.