Study of Ocular Manifestations of Hyperthyroidism

Background: Grave?s Orbitopathy(GO) also known as thyroid eye disease (TED), is the most common extrathyroidal manifestation of Grave?s disease. It is the most common cause of unilateral or bilateral proptosis in adults. In this auto-immune endocrine disorder, eye disease is characterized by inflammation of intra-orbital structures. Objective: To Study the prevalence of thyroid eye signs in patients of hyperthyroidism and to look for the most common thyroid eye signs and Symptoms associated with the disease. Materials and Methods: In this cross sectional study, 50 participants (diagnosed cases of hyperthyroidism) were enrolled. After Basic history taking and General physical examination, detailed Ophthalmological examination- ocular symptoms, visual acuity, detailed anterior segment examination, optic disc evaluation was done. Thyroid eye disease specific signs were noted and Hertel?s exophthalmometry was done. Frequency of eye symptoms and signs were noted and percentage was calculated. Descriptive analysis (frequency, percentage) was done. Chi square test was used to check statistical significance. Results and conclusion: There was female preponderance in thyroid eye disease in the study. The most common age group involved was 40-49 years. Bilateral involvement was 9 fold more common than unilateral Involvement. Smoking was a significant Risk factor in male patients. Most common eye symptom was foreign body sensation. Most common eye sign was Dalrymple sign.