Human Lacrimal Gland Regeneration - Present Status

The human lacrimal gland is an integral part of the lacrimal functional unit. It is an established component of the secretory immune system. Any changes/interruption in LG function results in the manifestation of an ocular surface disease such as dry eye disease. Despite a high prevalence, the current therapy for dry eye is not promising and lifelong. Advanced treatments have shown to be of limited success. This review gives an overview of the lacrimal gland anatomy, physiology and its role in establishing homeostasis. It also summarizes the current research and various treatments modalities in lacrimal gland regeneration and/or reconstruction.