Antiinflammatory of Jatropha curcas Leaf: Role of TNF-? and IL-1
Journal: International Journal of Science and Research (IJSR) (Vol.11, No. 8)Publication Date: 2022-08-05
Authors : Warsinah; Hanif Nasiatul Baroroh;
Page : 168-170
Keywords : Jatropha curcas; isolate; Cytokine; TNF-? dan IL-1;
Abstract
Jatropha curcas extract reported analgesic and anti-inflammation effects on albumin-induced mice and antiarthritis in Complete Freud's Adjuvant-induced mice. Phytochemical screening proves that Jatropha curcas contains flavonoid compounds, steroids, triterpenoids, alkaloids, saponins, and tannins. With a cellular approach, an invitro test can be known anti-inflammation mechanism of active compounds of Jatropha curcas leaves. In vitro tests can also be known expression of IL-1 and TNF? cytokine gene target of this research. The results showed that active isolates activity of TNF-? activity was 176, 967 ?g / ml, and the IL-1 activity was 1024.077 ?g / ml. The isolation was higher than the compound activity on TNF-? and IL-1. In each isolate after TLC, the isolates contained flavonoid and terpenoid compounds. The correlation between in vivo and in vitro provides clear scientific information about the pharmacodynamics of the active compounds.
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