Experience Using PRP Injection as an Adjuvant with Core Decompression & Fibula Strut Grafting for Grade 1 & 2 AVN Head of Femur

Introduction & purpose: As a pathological process, AVN of the femoral head is characterized by the vascularity of the femoral head, cellular necrosis, microfracture, and the collapse of the articular surface. Treatment for early stage AVN head of femur is limited to core decompression. To improve the core decompression efficacy, regenerative techniques such as the use of platelet - rich plasma were proposed for early stage AVN head of femur. In this review, we present a comprehensive overview of the efficacy of PRP for early - stage AVN head of femur. Material & Methods: A study was carried out in orthopaedics department from the month of April 2018 to September 2019, 17 patients with AVN head of femur stage 1 & 2 have been included in this study and have been followed up till September 2021 and have been evaluated based on HHS and VAS score system. Results: Among 17 patients with AVN head of femur stage 1 & 2 (9 males and 8 females) their mean HHS and VAS scores showed improvement after getting treated with core decompression with Fibulastrut graft along with PRP as an adjuvant. Conclusion: PRP plays an important role in tissue repair, regeneration, and the differentiation of mesenchymal stem cells so as an adjunctive therapy for core decompression, PRP is recommended to improve the treatment of early - stage AVN head of femur patients, especially when combined with bone grafts, by inducing osteogenic activity and stimulating the differentiation of stem cells in necrotic lesions.