Synthesis and Characterization of New Amide Drug from Cromoglicic Acid and Study of Their Possible Biological Activity

The research included preparing a high yield of new derivatives of cromoglicic acid have been created with new properties. Cromoglicic acid constitutes a major type of pharmaceutical organic compound. Its derivatives can be utilized in the manufacture of new types of drugs, possess a wide range of biological activity, and reduce side effects. The work included direct interaction for eight amino drugs (amoxicillin, ampicillin, folic acid, Mefenamic acid, Paracetamol, Theophenyl, cephalexin, and 4-aminoantipyrine) after converting acid into chloride using SOCl2 and DCM and the addition of (tri methylamine), T LC to control the chemical reaction and to characterize the new derivatives using FT-IR, 13CNMR and 1HNMR techniques. The antioxidant activity of the prepared compounds was examined by DPPH method and the results showed an excellent antioxidant activity of all these prepared compounds, much higher than that of ascorbic acid.