Acute Myeloid Leukemia with BCR-ABL1 Translocation: A Rare Entity
Journal: Haematology International Journal (HIJ) (Vol.5, No. 2)Publication Date: 2021-07-20
- Acute Myeloid Leukemia with BCR-ABL1 Translocation: A Rare Entity
- Characterization of Three-Way Translocation [t(4;9;22)(p16;q34;q11.2)] in Chronic Myeloid Leukemia
- Acute myeloid leukemia presenting with multiple breast and skin myeloid sarcomas: A case report
- Acute myeloid leukemia in a chronic lymphocytic leukemia patient: diagnostic challenge (clinical case)
- Acute cardiotoxicity after initiation of the novel tyrosine kinase inhibitor gilteritinib for acute myeloid leukemia
Abstract
Acute myeloid leukemia (AML) with BCR-ABL1 is a provisional entity in WHO classification of hematological malignancies and it is a denovo AML in which patients show no evidence of Chronic myeloid leukemia (CML) [1]. It accounts for <1 % of all AMLs and it primarily occurs in adults with male predominance [2]. Patients present with leucocytosis with blast predominance along with anemia and thrombocytopenia. Compared with CML patients less frequently splenomegaly and lower peripheral blood basophilia [3]. Morphological features include presence of peripheral blood and bone marrow myeloblasts showing minimal differentiation to granulocytic maturation. Average bone marrow cellularity is less than CML and dwarf megakaryocytes are also less common [2,3].
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