RESPONSE TO METHYLPREDNISOLONE BOLUS IN CHILDREN TREATED FOR NEPHROTIC SYNDROME AT THE PEDIATRIC NEPHROLOGY UNIT IN ABIDJAN
Journal: International Journal of Advanced Research (Vol.10, No. 09)Publication Date: 2022-09-13
Authors : Ehile-Kacou Assamala Marielle Sophie Diarrassouba Gnenefoly Lasme-Guillao Berthe Evelyne Bouah-Kamon Nasser Emmanuela NDraman-Donou Emma Eboua Tanoh Kassi Francois Kouadio Bherat Armel Ya Amenan Gisele Toure Rokiya;
Page : 228-232
Keywords : Bolus Of Methylprednisolone Corticosteroid Resistance Nephrotic Syndrome;
Abstract
Introduction: The objective of this study was to describe the modalities of the responses observed following the realization of a bolus of methylprednisolone in children treated for nephrotic syndrome in the pediatric nephrology unit in Abidjan in order to assess the need for its realization in our practice. Methods: we carried out a descriptive and analytical cross-sectional study in patients followed up in the pediatric nephrology unit for a nephrotic syndrome and having benefited from the administration of 3 boluses of methylprednisolone at a dosage of 1g/1.73m2 between 2013 and 2021. Results: we collected 33 patients aged 2 to 12 years in 72.7% of cases with a male predominance (sex ratio=2.66). The bolus indication was the persistence of proteinuria (100%) after four to six weeks of corticosteroid therapy at 60mg/m2. A biological assessment in search of a secondary cause had been carried out (48.8%) and presented abnormalities in 26.6% of cases. The bolus was done in hospitalization in 54.5% of cases. All patients benefited from gastric protection and a biological assessment before each bolus. During the realization of the bolus, incidents were observed (27.2%): arterial hypertension (22.2%), fever (55.5%), hyperglycaemia (11.2%). The post-bolus evaluation revealed 66.8% corticosteroid-resistant patients and 27.2% corticosteroid-sensitive. Conclusion: The bolus of methylprednisolone made it possible to catch up in a third of the cases of corticosteroid-sensitive patients, hence the need for its realization when the conditions allow it.
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