ResearchBib Share Your Research, Maximize Your Social Impacts
Sign for Notice Everyday Sign up >> Login

Development and Validation of Assay Method for Determination of Quetiapine Fumarate by RP-HPLC from Bulk and Pharmaceutical Dosage Form

Journal: International Journal of Pharmaceutical Sciences and Medicine (IJPSM) (Vol.7, No. 10)

Publication Date:

Authors : ; ; ;

Page : 65-96

Keywords : Pharmaceutical Dosage Form; Quetiapine Fumarate;

Source : Downloadexternal Find it from : Google Scholarexternal

Abstract

A simple, sensitive, rapid, robust and reproducible method for the determination of Quetiapine fumarate in bulk and pharmaceutical formulation (Tablets) was developed using reverse phase high performance liquid chromatographic method (RP-HPLC). The RP-HPLC analysis was performed The analyte was monitored with UV detector at 290nm. The developed method Quetiapine fumarate elutes at a run time of 10 min. The proposed method is having linearity in the concentration range from 40 to 80 μg/mL of Quetiapine fumarate. The present method was validated with respect to system suitability, linearity, precision, limit of detection (LOD) and limit of quantification (LOQ), accuracy (recovery), ruggedness, and robustness. The proposed method can be readily utilized for bulk drug and pharmaceutical formulation.

Last modified: 2022-10-15 23:11:04