HYPERPROLACTINEMIA AND ITS COMPARISION WITH HYPOTHYROIDISM IN INFERTILE WOMEN

Introduction :Human infertility is a complex global health problem. It has multiple social consequences which are especially profound for thyroid hormones in infertility with the aim of determining the degree of association of thyroid hormones with hyper prolactinemia in our population. Materials and method:In this study, we investigated women who were casesof infertility, who attended the Biochemistry Department, RV Metropolis, Bangalore, India, for hormonal evaluations. Thirty fertile women with similar ages were enrolled as the controls. The status of the thyroid dysfunction and the levels of serum prolactin were reviewed in infertile women and in the controls. The serum Prolactin and the thyroid stimulating hormone levels were measured by using Roche reagents in COBAS 8000 Instruments. Results: In our study, the serum prolactin levels in the infertile group were found to be high as compared to those in the control group and they were highly significant (p<0.0001). The serum TSH levels in the infertile group were found to be high, as compared to those of control group and they were highly significant (p<0.0001). Conclusion: It is therefore Concluded that hyperprolactinemia with thyroid dysfunction may be major contributory hormonal factor in infertility among infertile women and as such , estimation of prolactin and thyroid stimulating hormone should be included in the work up for infertile especially those with hyperprolactinemia.