Scientific Studies of The Activity and Acute Toxicity of Ld50 Rattan As A Natural Ingredient Drug in Suku Anak Dalam (Sad) Bukit Dua Belas Jambi, Indonesia: Review Articles

Scientific review of articles based on Indonesian local wisdom has been carried out, especially on the potential of 11 types of rattan in Suku Anak Dalam (SAD) jambi province, Indonesia. Scientific studies are carried out with reference to the same type of species, related to the study of their potential activity pharmacologically and toxicity studies on values LD50. The article review study was conducted using the PRISMA method. Retrieval of article sources from science direct, springer and pubmed databases is performed. Limitations are carried out related to data collection, that only take original research articles and review articles with article sources in English. Interesting data have been obtained here, no study of the pharmacological effect on 11 types of rattan has been carried out in this article review study. Rattan by species Daemonorops draco, Calamus scipionum, Calamus manan, Calamus ornatus, Calamus axillaris and Calamus caesius studies of pharmacological effects have been carried out. Only on Daemonorops draco obtained data that is quite capable and gets attention by world researchers because it is known to have the potential for anti-cancer activities. However, in other types of rattan, the data obtained is not so much and it is still very feasible to conduct a study search on drug discovery based on natural product sources as drug candidates. Rattan by species Calamus fabellatus, Calamus javensis, Korthalsia echinometra and Daemonorops geniculate no scientific studies have been found related to its potential activities pharmacologically. In the study of acute toxicity LD50, has not been done at all on the 11 types of rattan. In conclusion, the "Gap of Science" of the topic of rattan available on the environment Suku Anak Dalam (SAD) Bukit Dua Belas Jambi Province still has great potential for scientific and in-depth studies related to the potential and study of drug discovery by utilizing natural product sources that can be done by all researchers with an interest in natural products as a source of treatment.