ACUTE TOXICITY TEST OF ETHANOL EXTRACT OF SUNGKAI LEAF (Peronema canescens Jack) IN WHITE MICE (Mus musculus)

Sungkai (Peronema canescens) is a type of plant that can be used in traditional medicine in Jambi, Indonesia. The purpose of the study was to determine the value of LD 50 from the results of the acute toxicity test of LD 50 ethanol extract of Sungkai leaves (Peronema canescens) in male and female white mice (Mus musculus). This research method is experimental research in the laboratory used 50 mice comprising 25 males and 25 females which are divided into 5 groups, normal control (Na-CMC 1%), ethanol extract (625 mg/kg body weight), ethanol extract (1,250 mg/kg body weight), ethanol extract (2,500 mg/kg body weight) and ethanol extract (5,000 mg/kg body weight). The test preparation is administered orally through the gastric sonde and is administered only once in 24 hours. The Indonesian Pharmacopoeia Edition III method was used to calculate the value of LD 50 in this study. The results of the acute toxicity test of LD 50 Sungkai leaf ethanol extract are included in the safe category in the male animal group. In the group of female animals, an LD 50 value of 6.50 mg/kg body weight was got. They include it in the category of very toxic and dangerous for the group of female animals. On the data on the ratio of organ weights in each research organ. Only in the male group, there was no noticeable difference (P>0.05) in each organ, but in the female group of animals, there were noticeable differences (p<0.05) in the heart, liver, lungs, kidneys, and stomach organs.