The Role of Oxidative Stress in Molar Pregnancy

A molar pregnancy is the result of an abnormally fertilized egg or placental tissue expansion. The goal of this research was to investigate the potential linkage between some biochemical tests, antioxidant enzymes, oxidative stress, and fatty acid compositions in patients with a molar pregnancy compared with healthy pregnancy subjects. An observational case-control study was conducted in Mosul, Iraq. In this study, 141 women participated, and they were split into three group: 45 patients with molar pregnancy, 47 women with healthy pregnancy, and 49 healthy control women. Antioxidant enzymes, lipid peroxidation, hCG, ALP, trace elements, and fatty acid compositions were all investigated. The results revealed that MAD and hCG levels were increased in molar pregnancy compared with healthy pregnancy, while paraoxonase and GSH levels were decrease in molar pregnancy women than in healthy pregnant women. Likewise, the results showed that the increase of saturated fatty acids in molar pregnancy women was greater than in healthy pregnancy. This study found a significant rise in oxidative stress and poor monounsaturated and polyunsaturated fatty acid status in molar pregnancy as well as increased saturated fatty acids.