Formulation and Evaluation of Organo-Transdermal Gel of Drug Ibuprofen

The current research project is centered on the development and assessment of an Ibuprofen topical gel made with Guar gum as the polymer and Carbopol 940 as a penetration enhancer. [ Gels were made by dispersing the polymers in a solution of guar gum and isopropyl myristate, along with Carbopol 940, glycerol as aqueous agents, and potassium sorbate as preservative, and different concentrations of ibuprofen, all while maintaining magnetic stirring. Triethanolamine was then added to the dispersion to neutralize it and make it viscous. Ibuprofen - Guar gum gels were discovered to be homogeneous and to have adequate drug loading. All of the gel compositions' pH values fell within the range of neutral pH, which is suitable for skin. And it was discovered that the compositions' viscosity was suitable for topical use the drug content of the nine formulations was found in the range of 80% to 90% which shows efficient drug loading. The compatibility study showed that the major peaks in FTIR spectra of the pure drug were found to be intact in their physical mixture. Hence there is no interaction between the drug and Carbopol, drug and Guar Gum in their physical mixture. Guar gum can be effectively used as a polymer with Carbopol 940.