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Preparation and Identification of New 1,4-bis (5,3-substituted-2,3-dihydro-1H-pyrazole-1-yl) Buta-1,4-Dione Derivatives with Their Antibacterial Effect Evaluation

Journal: Chemical Methodologies (Vol.7, No. 2)

Publication Date:

Authors : ; ; ; ;

Page : 123-136

Keywords : Pyrazole; Cyclization; Succinicdihydrazide; Chalcones; Butadione; Antibacterial Effect;

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Abstract

A new series of 5,3-substituted-2,3-dihydro-1H-pyrazole derivatives (P1-10) have been synthesized via a cyclization reaction of substituted chalcones with succinichydrazide. Structures of the prepared compounds were identified by FT-IR, and some of them were characterized by Nuclear Magnetic Resonance for proton 1H-NMR and Nuclear Magnetic Resonance for carbon 13C-NMR. The heat of formation (HF) and steric energy (SE) have been calculated using (MOPAC) and (MM2) methods, respectively, using (CS-Chemoffice-version 6.0) program. Additionally, the biological activity for final products has been evaluated against gram-positive (staphylococcus aureus and staphylococcus epidermidis) and negative bacteria (escherichia coli and pseudomonas aeruginosa). 

Last modified: 2022-12-07 04:23:53