Synthesis, Characterization and Antimicrobial Activity of Isoxazoline Derivatives

In present study isoxazoline derivatives were synthesized and antimicrobial activity of different derivatives were checked with various microbial stain. Various intermediates was synthesized and characterized in between time to time by chromatography using TLC. An isoxazoline series of compounds were synthesized by condensation reaction of phenyl ethyl acetate with substituted benzaldehyde in presence of alcoholic sodium hydroxide to get intermediate phenethyl cinnamate (chalcones), which were further treated with hydroxylamine hydrochloride in presence of sodium hydroxide to get isoxazoline derivatives. The synthesized compounds were characterized on the basis of their spectral (IR) data and evaluated for the antimicrobial activity by using Zone of Inhibition by cup plate method.