Effect of Nanoparticles of Ocimum Basilicum Methanolic Extract on Rat's Liver

Ocimum basilicum is a popular herb used in traditional medicine and as a typical ingredient of the healthy diet. The current investigation aimed to evaluate the nontoxic effect of methanolic basil extract. Two groups of twenty rats were used for 8 weeks: group G1 (control) and group G2 (Ocimum basilicum treated). Serum liver function and serum lipid profile were measured using Elisa Kits, and histological studies were affected. No significant changes in levels of alkaline phosphatase (ALP), Alanine Aminotransferase (ALT), and aspartate aminotransferase (AST) were detected. Furthermore, no significant changes are observed in the levels concentration of triglycerides (TG), total cholesterol (TC), and low-density lipoprotein (LDL), comparing O. basilicum group with control croup. However, moderate decreasing is observed in the concentration of High-Density Lipoprotein (HDL). Other, no histological changes were observed in the liver of O. basilicum group comparing with the control group. Our study suggests that, the sweet basil methanolic extract appears to be nontoxic.