Morphological pattern of non-diabetic nephropathy in type 2 diabetes mellitus patients
Journal: Ukrainian Journal of Nephrology and Dialysis (Vol.2, No. 74)Publication Date: 2022-06-15
Authors : Meral Mese; Serap Yadigar; Ergün Parmaksız;
Page : 38-44
Keywords : diabetic nephropathy; non-diabetic nephropathy; kidney biopsy; glomerulonephritis; proteinuria;
Abstract
The aim of this study was to evaluate the contribution of kidney biopsy performed with an appropriate indication to diagnosis and treatment in diabetic patients with nephropathy. Methods: In this retrospective study 32 type 2 diabetes patients who underwent kidney biopsy in a single center between 2012-2019 were included. Kidney biopsy indications were determined as patients with diabetes without diabetic retinopathy and with proteinuria above 1 g/day. Results: Diabetic (DN) and non-diabetic (NDN) nephropathies were diagnosed with renal biopsy. In 14 (43.7%) of 32 patients, NDN was reported in histopathological evaluation. Membranous nephropathy was detected in 4 of these patients, focal segmental glomerulosclerosis (FSGS) in the other 4 patients, light chain disease in 2 patients, IgA nephropathy in 2 of the patients, minimal change nephropathy in another patient, and finally AA amyloid in one patient. NDRD seen superimposed on DN (DN + interstitial nephritis and DN + FSGS) was observed in 2 patients. DN was detected in 16 (50%) of 32 type 2 diabetic patients. Conclusion: Kidney biopsy in patients with type 2 diabetes is an important tool for diagnosing NDN, choosing the right treatment tactics and determining kidney prognosis.
Other Latest Articles
- Malabsorption syndrome aggravates calcium homeostasis impairment in chronic kidney disease patients
- Serum soluble Fas-ligand levels and flow-mediated vasodilation in patients undergoing peritoneal dialysis
- Pilot testing for long-term impact of glycerol-induced acute kidney injury on oxalate homeostasis in rats
- Assocıatıon of serum urıc acıd level wıth dısease severıty and clınıcal outcomes ın COVID-19
Last modified: 2022-12-22 20:51:04