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Formulation and Evaluation of Controlled Release Tablet of Irbesartan

Journal: International Journal of Pharmaceutical Sciences and Medicine (IJPSM) (Vol.7, No. 12)

Publication Date:

Authors : ; ;

Page : 71-83

Keywords : Controlled release; Matrix tablets; Irbesartan; HPMC;

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Abstract

The main aim of present work was to formulate and evaluate controlled release matrix tablets of Irbesartan. It releases drugs at fixed and expected rate in a controlled manner either by dissolution and diffusion control mechanism. The matrix tablet was prepared by wet granulation method using by various concentration of HPMC and ethyl cellulose with combination of various release retardant polymer. The powder mixtures were subjected to various pre- compression parameters such as angle of repose, bulk density, tapped density and Carr's index shows satisfactory result and the compressed tablets are evaluated for post- compression parameters such as weight variation, thickness, hardness, friability, drug content and in- vitro dissolution studies. In- vitro dissolution studies were carried out for 24 hours using 0.1N HCL for first 2 hours and ph 6.8 phosphate buffers for 24 hours and the result showed that formulations F3 and F4 show good dissolution profile to control the drug release respectively. The drug content of the formulation was determined by using 0.1 N HCL at 262nm. The drug content was maximum with formulation F5 and minimum with formulation F3.

Last modified: 2022-12-24 17:13:58