Experimentally Justified Choice of Optimal Antiseptic Solution for Hygienic Care of Oral Cavity and Dentures

INTRODUCTION: The range of antiseptic agents used in clinical practice, is rather wide. However, only single studies are devoted to comparative characteristics of their effectiveness in the conditions of the oral cavity. AIM: To choose the optimal antiseptic dental cleaner by experimental study. MATERIALS AND METHODS: An aqueous solution of Furacilin® (0.02%), chlorhexidine bigluconate (0.05%), Miramistin® (0.01%), cetylpyridinium chloride (0.05%), hydrogen peroxide (3%), Iodinol®, Rotokan®, distilled water were used as washing liquids for elimination of dental plaque. The model of the dentition was created from quartz plates with an imitation of fresh plaque. Biomaterial imitating dental plaque included two solutions: 1) a strong fresh infusion of black tea leaves, cooled to +25°C; 2) oatmeal jelly with temperature from +60°C to +65°C. The authors' method of screening dental cleaners was used, based on comparing the transparency of the laboratory model of the dentition before and after exposure to the test solution by determination with an amperemeter of strength of the electric current in the photosensor device from the oxyhemograph sensor after white light emitted by a mini-emitter passed through biological material and plates and fell on it. RESULTS: The cleaning capacity of distilled water is the lowest (p < 0.05–0.001). Rotokan®, Furacilin® and Iodinol® have a low cleaning capacity, and Iodinol® can cause a burn of the gingival cuff in case of high reaction to it, and allergic reactions. Hydrogen peroxide has an average degree of efficiency, but it dries the oral mucosa. Chlorhexidine bigluconate has the highest cleaning effect, Miramistin® and cetylpyridinium chloride are slightly inferior to it (p > 0.05). By the cleaning capacity, chlorhexidine bigluconate solution is significantly superior to hydrogen peroxide (p < 0.05), Iodinol® (p < 0.02), Furacilin® (p < 0.02), Rotokan® (p < 0.01). CONCLUSION: The described method received the patent for invention of the Russian Federation No. 2019121293. Experimental studies have shown the best cleaning effect of 0.05% solution of chlorhexidine bigluconate.