UNDIFFERENTIATED CONNECTIVE TISSUE DYPLASIA AS A RISK FACTOR OF GESTATIONAL COMPLICATIONS
Journal: Journal of the Grodno State Medical University (Vol.20, No. 6)Publication Date: 2023-01-13
Authors : T. V. Novitskaya;
Page : 637-641
Keywords : undifferentiated connective tissue dysplasia; pregnancy; childbirth; postpartum period; minor heart abnormalities; placental disorders;
Abstract
Objective. To establish the value of undifferentiated connective tissue dysplasia (UCTD) as a risk factor for complications of pregnancy and labor. Material and methods: A prospective, cohort, randomized, controlled trial was conducted. Taking into account inclusion and exclusion criteria, the study included 228 women aged 18-42 years. 2 groups have been formed. The main group was 125 patients. The comparison group was 103 pregnant women with no signs of undifferentiated connective tissue dysplasia. The features of the menstrual cycle, the course of pregnancy and childbirth and perinatal outcomes were studied. Results. The role of UCTD is demonstrated as a risk factor in the development of pregnancy and childbirth complications: the presence of UCTD increases the likelihood of the threat of termination of pregnancy in the first trimester by 2.7 times, in the second and third trimesters by 3.4 and 3.9 times, respectively. Among pregnant women with manifestations of UCTD, the probability of developing placental disorders was 227% (CI 172.6-281.4) higher than in the control group. Conclusion. Optimization of the management of the preconception period, pregnancy and childbirth in patients with UCTD will improve perinatal outcomes.
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