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Evaluation of interactions of silibinin with the proteins ALS3 and SAP5 against Candida albicans
Journal: Journal of Health and Biological Sciences (Vol.10, No. 1)Publication Date: 2022-01-05
Authors : Cecília Rocha da Silva; Francisca Lariza Damacieira Moura; André Luis Almeida Alves Filho; Rosana de Sousa Campos; Vitória Pessoa de Farias Cabral; Lívia Gurgel do Amaral Valente Sá; et al;
Page : 1-6
Keywords : silibinin; fungal infection; candida spp; molecular docking; adhesion proteins;
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Abstract
Objective: to evaluate the molecular interaction of silibinin with the targets ALS3 and SAP5. Methodology: Molecular docking protocols were conducted to analyze the binding interaction of silibinin with ALS3 and SAP5. Results: Eleven interactions of ALS3 with silibinin and four with fluconazole were found, while six interactions were observed of SAP5 with silibinin and four with fluconazole. Conclusion: Molecular docking between silibinin and ALS3 identified important interactions, but no significant interactions were observed with SAP5, even though silibinin can exhibit affinity and interactions with other SAP5 sites.
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Last modified: 2023-01-21 05:55:02