Characterisation of Solid Dispersions of Nisoldipine Prepared By Solvent Evaporation Method and Hot Melt Method

Background: Drug with poor aqueous solubility will typically exhibit dissolution rate limited absorption and drug with poor membrane permeability will typically exhibit permeation rate limited absorption. Nowadays pharmaceutical industry mainly focuses on improving the oral bioavailability of active agents by enhancing solubility and dissolution rate of poorly water-soluble drugs. Methods: Aim of the study was to improve the physicochemical properties of Nisoldipine, a poor water soluble drug by forming dispersion with water soluble carrier. The solid dispersions (SDs) of Nisoldipine with PEG6000 and mannitol were prepared by 1:1:1:3 and 1:5 (Nisoldipine/PEG 6000/Mannitol) ratios by Solvent evaporation method and Melt method. Results: Evaluation of properties of the solid dispersion was performed by using Fourier Transform IR (FTIR), X-ray diffraction (XRD), Estimation of drug content and Dissolution studies. The SDs of nisoldipine with PEG 6000 exhibited enhanced dissolution rate of Nisoldipine vs. Mannitol. Conclusion: Solid dispersions of Nisoldipine: PEG 6000 prepared as 1:5 ratio by solvent evaporation method showed excellent physicochemical characteristics and was found to describe by dissolution was selected as the best formulation in the study.