Genes in Tumor Formation
Journal: Journal of Hematology and Oncology Research (Vol.3, No. 2)Publication Date: 2018-10-04
Authors : Isolde Riede;
Page : 18-22
Keywords : Oncogenes; Tumor Suppressor Genes; Proliferative Genes; Switch Genes;
- Genes in Tumor Formation
- Strong Down-Regulation of Tumor Suppressor Genes RB1 and CTDSPL is Associated with Aberrant Expression of Cell Cycle Regulation Genes in Non-Small Cell Lung Cancer
- Review on Tumor Suppressor Genes and their Interplay in Breast Cancer: The Caretakers
- REVERSAL OF HYPERMETHYLATION AND REACTIVATION OF TUMOR SUPPRESSOR GENES DUE TO NATURAL COMPOUNDS IN BREAST CANCER CELLS
- Evaluation of Beclin1 and mTOR genes and p62 protein expression in breast tumor tissues of Iranian patients
Abstract
With the definition of four gene classes, all differences between tumor cells and normal cells can be explained. Proliferative mutations induce a shortcut, forcing the cell to divide. They allow replication without control, induce somatic pairing defects of chromosomes and genome instability. Intact Tumor Supressors or mutant Switch Functions can inhibit this process. Oncogene mutations optimize the growth of the cells.
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