An Analytical Study of NSAIDs Affecting Heart Functions
Journal: International Journal of Bio-Medical Informatics and e-Health (IJBMIeH) (Vol.10, No. 6)Publication Date: 2022-12-15
Authors : Ajeem Hamed Ajeem Almoutared Melfi Dahen Ziad AlSinan Mohammed Manea M Zabarah Mzabarah Saleh saud saleh Al salem Hussein Mana Alzmanan;
Page : 11-17
Keywords : Medical; Drugs; Nonsteroidal; Anti- inflammatory Medicines; Diclofenac; heart functions;
Abstract
Local production of vasodilating prostaglandins is necessary to sustain renal perfusion in a number of clinical situations, such as congestive heart failure, cirrhosis, and renal insufficiency. Inhibition of these prostaglandins permits unopposed vasoconstriction to occur when patients with these illnesses are given nonsteroidal anti-inflammatory medicines (NSAIDs), putting them at risk for an acute ischemic insult to the kidney. Acute kidney injury (AKI) and chronic kidney disease are only two of the many nephrological problems that can result from using NSAIDs (CKD). Nonsteroidal anti-inflammatory medicines (NSAIDs) have been shown to increase blood pressure and to antagonize the blood pressure-lowering action of antihypertensive therapy, both of which have the potential to enhance hypertension-related morbidity. Diclofenac was the drug that caused the most noticeable decrease in COX-2 activity, increase in blood pressure, and decrease in heart rate. In a complicated way, non-aspirin, non-steroidal anti- inflammatory medicines (NANSAIDs) can either protect against or contribute to the development of coronary heart disease. The cardiovascular effects of all the medicines studied were unclear, although Naproxen looked the safest. When compared to lumiracoxib, the findings show that ibuprofen may increase the incidence of thrombotic and CHF events in aspirin users with high cardiovascular risk. Before giving a non-steroidal anti-inflammatory medicine, doctors should evaluate the patient for cardiovascular risk.
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