Synthesis and Antimicrobial Activity of New 4-Fromyl Pyrazole Derivatives Drived from Galloyl Hydrazide
Journal: Chemical Methodologies (Vol.7, No. 4)Publication Date: 2023-04-01
Authors : Fayyadh Abed Nashaan; Muna Sameer Al-Rawi;
Page : 267-276
Keywords : Galloyl hydrazine; Pyrazole; Yilsmeyr Hatchh formylation reaction; Hydrazine; Gallic acid;
Abstract
The new compounds of 3-substituted phenyl-5-(3,4,5-trihydroxyphenyl)-4H-pyrazole-4-carbaldehyde [III]a-e were synthesized by reacting various hydrazones derived from galloyl hydrazide with different substituted aromatic ketones using phosphoryl trichloride in dimethylformamide as a solvent. The newly synthesized derivatives were elucidated using FT-IR, 1H-NMR and mass spectroscopy. The antimicrobial activity of these derivatives was examined using two types of pathogenic bacteria and most of the derivatives exhibited excellent and good efficacy contra these species of bacteria using ampicillin as standard.
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