Study of Antioxidant and Membrane Resistant Peculiarities of a New Cyan Containing Lactone in Membranes of Hepatocytes with Sarcoma-45

The antioxidant and membrane resistant peculiarities of a new derivative (2-cyan-3,4,4-trymethil-2-buten-4 -olyd) of cyan containing unsaturated lactones have been studied in membranes of hepatocytes with Sarcoma-45 [1]. The results of our previous research [1, 2, 3] showed significant changes of phospholipid exchange in hepatocytes of microsomal membranes at experimental animals vaccinated with Sarcoma-45 tumor strain. It is manifested in significant changes of quantitative and qualitative contents of membrane phospholipids separate fractions, increase of cytotoxic LPCs, PIs and PAs levels, significant decrease of PCs and SPs contents, statistically significant changes of PL/PL ratio, peroxidation ratio intensity, dramatic increase of PLA2 activity, quantitative and qualitative changes of adenyl nucleotides, as well as disorders of ATPase system activity [3-5, 6, 7].