In Silico Inhibition of Essential Candida albicans Proteins by Arenicin, a Marine Antifungal Peptide
Journal: International Marine Science Journal (Vol.1, No. 1)Publication Date: 2019-01-22
Authors : Lívia do Carmo Silva; Andreia Marcelino Barbosa; Isabele Pereira Tannous; Thaynara Gonzaga Santos; Juliana Santana de Curcio; Lucas Nojosa Olive; Marielle Garcia Silva; Amanda Alves de Oliveira; Raisa Melo Lima; Kleber Santiago Freitas e Silva;
Page : 1-9
Keywords : Arencin; marine antifungal peptide; small bioactive molecules;
Abstract
Fungal infections increased substantially in the last years, becoming a relevant public health problem. Many of these infections account for high rates of morbidity and mortality. The emergence of resistant fungal clinical isolates have also motivate studies to find new antifungal therapies. Candida albicans is an oportunistic pathogen and affects a great number of immunocompromised patients worldwide. The marine ecosystem has been considered a rich source of bioactive metabolites due to the complexity and originality of its structures. Proteins and peptides from marine organisms have been shown to have antiviral, anti-inflammatory, antimalarial, anticancer, antimicrobial and antifungal properties. Arenicins are antimicrobial peptides isolated from the marine lugworm Arenicola marina with 21 amino acid residues in a β-hairpin structure. Dihydrofolate reductase, exo-b-(1,3)-glucanase and sterol 14α-demethylase are essential C. albincas enzymes that take part in DNA, cell wall and membrane metabolism, respectively. The present study evaluates the interaction of arenicin with important enzymes of C. albicans related to cell wall, ergosterol and DNA metabolism in order to elucidate possible molecular targets. We showed through an in silico approach, that a single compound from a marine worm (A. marina), can bind to three C. albicans essential proteins. The interaction occurs in regions inside the active site or at least near, with amino acid residues evaluated as hot spots. Arenicin is a new promising antifugal drug. The next step is to investigate protein-protein interactions performed by DHFR, EBG and CYP51 and assess whether arenicin is able to disrupt essential interaction or not.
Other Latest Articles
- INTRODUCING ELECTROMAGNETIC ENERGY FROM HYDROCOLLOID WOUND DRESSING PASTE PENETRATING A GLASS BARRIER DISRUPTING HUMAN SKINLIPID DROPLETS SIZE AND MEMBRANES: POSSIBLE IMPLICATIONS IN CANCERCELLS GENESIS AND/OR CURE
- PREVENTION AND DETECTION OF INTRUSION IN CLOUD USING HIDDEN MARKOV MODEL
- FEMALE AUTO-DRIVERS: AN EXPLORATORY STUDY OF THE OPPORTUNITIES AND CHALLENGES OF THE NON-TRADITIONAL LIVELIHOOD IN THANE DISTRICT
- ENHANCING THE PROTECTION PROPERTY ON SILK FABRIC BY THE TREATMENT OF POLYACRYLIC ACID AND CHITOSAN
- ASSESSMENT OF KNOWLEDGE AND PRACTICE OF CHILD CARE AMONG MOTHERS OF ONE TO THREE YEARS CHILDREN IN A SELECTED RURAL AND URBAN COMMUNITY. KOLKATA, WEST BENGAL
Last modified: 2023-02-28 21:01:07