Study of Some Heterocyclic Compounds Made from a New 4(3H)-Quinazolinone and Their Biological and Antioxidant Activities

The present study aimed at synthesizing new anti-inflammatory quinazolinone derivatives containing heterocyclic moieties by several methods and evaluates their in vitro anti-inflammatory, anti-oxidant, and biological activities. The chemical structures of the compounds synthesized were confirmed by spectral analysis, such as FT-IR, UV, GCMS, and 1H-NMR. The anti-inflammatory effect of these compounds was evaluated using the inhibition of denaturation method of bovine serum albumin (BSA) and the results have shown significant in vitro activity. The antioxidant activity was evaluated using nitric oxide with a hydroxyl radical scavenging assay, which showed a potential in radical scavenging due to the of electron donating substituent existence on substituted aldehydes. The antifungal and antimicrobial activity of the synthesized compounds against Fungi (C.albicans and A.niger), gram-positive (S.aureus and S.pyogenes) and gram-negative (E.coli and P.aeruginosa) have been studied. The results showed a high activity against gram negative bacteria (E.coli and P.aeragines) appeared for all compounds except for compound (1a) which showed a moderate activity against E. coli and weak against (P.aeragines). More studies are required to check confirm the antioxidant and biological activities of quinozalinone derivatives.