Study evaluating the ability of Fe-BDC-PEG to carry and release active ingredient 5-fluorouracil
Journal: International Journal of Advanced Engineering Research and Science (Vol.10, No. 03)Publication Date: 2023-03-27
Authors : Thu Hanh Pham Thi Hoai Phuong Nguyen Thi;
Page : 044-048
Keywords : Metal-organic framework; 5 Fluorouracil; drug carrier; ultrasonic method.;
Abstract
This paper presents the results of 5 fluorouracil carrying-release of iron (III) framework materials with two ligands of 1,4-benzene dicarboxylic acid and polyethylene glycol diacid synthesized by ultrasonic bath method at room temperature. Materials were characterized, and their properties by scanning electron microscopy (SEM) and infrared spectroscopy (FT-IR) techniques showed that the active ingredient was fully adsorbed into the structural framework of the material without changing the shape and size of the material. The evaluation results for the 5-fluorouracil carrying capacity of Fe-BDC-PEG two-ligand Fe-BDC-PEG framework material showed that the drug absorption capacity reached 358.707 mg/g. The slow-release characteristics of the material were also evaluated, indicating that the effective release of the active ingredient came to 94.42% after 7 days, and the maximum after 10 days reached 97.68%. The Fe-BDC-PEG@5-FU drug carrier material system is studied to orient the application of cancer treatment when minimizing side effects based on the slow release of the system.
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Last modified: 2023-03-27 13:24:26