LES ASPECTS EPIDEMIOLOGIQUES ET EVOLUTIFS DE LA SARCOIDOSE MEDIASTINOPULMONAIRE AU SEIN DU SERVICE DE PNEUMOLOGIE CHU HASSAN II FES

Introduction:Sarcoidosis is a non-necrotizing systemic granulomatosis of unknown cause characterized by a predominant pulmonary tropism. It is a disease of very variable manifestation and evolution. Its evolutionary course is difficult to predict: from spontaneous resolution in the absence of treatment to progressive organ destruction despite several lines of therapy. Objectives: The aim of our study is to describe the evolutionary profile of mediastinopulmonary sarcoidosis followed in the pneumology department of CHU Hassan II Fez. Material and methods:This is a retrospective study, covering the cases of mediastinopulmonary sarcoidosis followed in our department between January 2016 and December 2019 we required a follow-up period of at least 3 years to be able to retain the cure. Results:We collected 41 patients, the average age was 45.68 years (28-65), with a clear female predominance, 95 ,1% of women, type I was found in 12.2% of cases, type II in 73.2% of cases, type III in 7.3% of cases, and type IV in 7.3% of cases also. Histological confirmation was obtained by mediastinoscopy in 41.5% of cases, and by staged bronchial biopsies in 46.4% of cases. We opted for a therapeutic abstention in 46.3% of the cases (19 patients), 3 of them required treatment during their follow-ups. 22 patients required treatment with oral corticosteroids from the start, 4 relapses were noted after stopping corticosteroids, 4 patients required a second line of azathioprine, and 15 patients were cured after at least 3 years of no treatment.