A Review on Grignard Reagent
Journal: International Journal of Pharmaceutical Sciences and Medicine (IJPSM) (Vol.8, No. 4)Publication Date: 2023-04-30
Authors : Patil Ravindra; Dabade Sapna;
Page : 132-142
Keywords : Grignard reagents; alkylation; aldehydes; ketones;
Abstract
Grignard reagents are highly reactive organomagnesium halides formed by the reaction of magnesium metal with alkyl or alkenyl halides. They are very strong bases and react with acidic hydrogens such as alcohols, water and carboxylic acids. They are generally produced by reacting an aryl halide or an alkyl halide with magnesium. Grignard compounds are popular reagents in organic synthesis for creating new carbon-carbon bonds. For example, when reacted with another halogenated compound R'−X' in the presence of a suitable catalyst, they typically yield R−R' and the magnesium halide Mg-XX' as a by-product; and the latter is insoluble in the solvents normally used. Pure Grignard reagents are extremely reactive solids. They are normally handled as solutions in solvents such as diethyl ether or tetrahydrofuran; which are relatively stable as long as water is excluded. In such a medium, a Grignard reagent is invariably present as a complex with the magnesium. atom connected to the two ether oxygens by coordination bonds. Grignard reagents react with a variety of carbonyl derivatives. The most common application of Grignard reagents is the alkylation of aldehydes and ketones, i.e., the Grignard reaction.
Other Latest Articles
- Evaluation of Anti-Inflammatory Activity of Gum Resin Extract of Boswellia Serrata
- REACTION LEUCEMOIDE EOSINOPHILE AU COURS DUN LYMPHOME DE HODGKIN
- ADVERSE SKIN MANIFESTATIONS FOLLOWING THE ADMINISTRATION OF COVID-19 VACCINATION:REPORT OF 48 CASES
- A CROSS SECTIONAL STUDY TO ASSESS THE CLINICAL PROFILE OF ACUTE KIDNEY INJURY DURING PREGNANCY AND PUERPERIUM IN A TERTIARY CARE HOSPITAL OF CENTRAL INDIA
- STUDY OF EXTENDED SPECTRUM BETA LACTAMASES & BIOFILM IN PSEUDOMONAS SPECIES ISOLATED FROM DIFFERENT CLINICAL SAMPLES
Last modified: 2023-05-05 21:19:06