STUDY OF SERUM URIC ACID LEVELS IN CIRRHOSIS OF LIVER AND ITS CORRELATION WITH CHILD PUGH SCORE

Background: Liver cirrhosis is one of the most common causes of morbidity and mortality. Elevated serum uric acid (UA) levelsstrongly reflect progression of liver disease. Child Pugh Scoreused to assess the severity of cirrhosis of liver. The present study was undertaken toestimate the level of serum UA in liver cirrhosis patients and its association with the child Pugh score. Method: A total 70 patients diagnosed with cirrhosis of liver, aged above 20 years were included in the study. For each patient, a modified Child Pugh Score were calculated. Blood samples were collected, and hematological and biochemical tests were performed. Results: The mean serum UA level was 7.53mg/dl, and it was raised in patients with liver cirrhosis disease in relation to its severity. Alcoholic liver disease was the most common etiology for liver cirrhosis (80%). The mean serum AST and ALT level was 72.8mg/dland42.07mg/dlrespectively, theywere not increasing with increase in serum UA level. Whereas mean serum total bilirubin level and INR value was 2.73mg/dl and 2.02mg/dl respectively, they increasedwith increase in serum UA level. The mean serum albumin level was 2.6mg/dl and it decreased withincrease in serum UA level. Serum UA levels increased as CTP score increased. Maximum UA levels were found in CTP class C (Mean 9.23mg/dl) and maximum mean UA levels (6.6mg/dl) were noted in alcoholic liver disease. Conclusions: Serum UA level is an important part of spectrum of liver cirrhosis disease.UA is a mediator of inflammation and tissue damage thus, itmay be considered as a marker of severity of liver cirrhosis disease.