Emerging Trends in T-cell based Vaccines |Biomedgrid

Since Edward Jenner's first use of cowpox pustules against smallpox to the present use of subunit vaccines, vaccinology has seen a paradigm shift. The transition from time-intensive microbiological approaches to the current machine learningbased prediction algorithms for epitope identification have enabled the development of faster, cost-effective and efficient vaccines. However, to outrace the newer and deadlier emerging pathogens, our approach to vaccination needs to be constantly modified. As we mark the final year of the Decade of Vaccines and its product Global Vaccine Action Plan (GVAP), we emphasize the significance of T- cell responses to achieve a successful vaccination. While the traditional vaccination approaches mostly relied on antibody generation as a measure of vaccine efficacy; recent years have seen a rekindled interest in T- cells' role for immunoprotection. In fact, current vaccination approaches against a number of pathogens are exclusively designed to elicit T- cell-based immune response.