Tetracyclic Condensed Pyrimidines. New Derivatives of the Benzo [4’,5’] Imidazo [2’,1’:6,1] Pyrido [2,3-D] Pyrimidines |Biomedgrid
Journal: American Journal of Biomedical Science & Research (Vol.7, No. 6)Publication Date: 2020-03-03
Authors : Harutyunyan AA; Ghukasyan GT; Safaryan MS; Grigoryan AS; Danagulyan GG;
Page : 470-471
Keywords : Heteroaromatic; Methodology; Fragments; Pyrimidines; Monoaminoxidase;
Abstract
The biological activity of polycyclic heteroaromatic compounds is due to their ability to interact with DNA, being associated with small and large grooves or intercalation between adjacent bases in a double helix, the interaction mechanism of the latter being considered as the main one. In both cases, the secondary structure of DNA is distorted and its functioning is disrupted, and therefore the connections with this mechanism of action are considered as the most promising in developing new-generation drugs for the treatment of tumor diseases and viral and bacterial [1].
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