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Tetracyclic Condensed Pyrimidines. New Derivatives of the Benzo [4’,5’] Imidazo [2’,1’:6,1] Pyrido [2,3-D] Pyrimidines |Biomedgrid

Journal: American Journal of Biomedical Science & Research (Vol.7, No. 6)

Publication Date:

Authors : ; ; ; ; ;

Page : 470-471

Keywords : Heteroaromatic; Methodology; Fragments; Pyrimidines; Monoaminoxidase;

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Abstract

The biological activity of polycyclic heteroaromatic compounds is due to their ability to interact with DNA, being associated with small and large grooves or intercalation between adjacent bases in a double helix, the interaction mechanism of the latter being considered as the main one. In both cases, the secondary structure of DNA is distorted and its functioning is disrupted, and therefore the connections with this mechanism of action are considered as the most promising in developing new-generation drugs for the treatment of tumor diseases and viral and bacterial [1].

Last modified: 2023-05-30 21:31:06