BIOPSY PROVEN ACUTE INTERSTITIA NEPHRITIS SECONDARY TO NON-STEROIDAL ANTI-INFLAMMATORY DRUGS ABUSE IN A SIXTY TWO YEAR OLD MAN
Journal: International Journal of Advanced Research (Vol.11, No. 04)Publication Date: 2023-04-14
Authors : Uduagbamen P.K Shitu A.O Ano-Edward GH Idris S.O Kasali O.E; Dairo I.O;
Page : 10-14
Keywords : Acute Interstitial Nephritis Non-Steroidal Anti-Inflammatory Drugs Haemodialysis Acute Kidney Injury;
Abstract
Acute interstitial nephritis (AIN) can be caused by non-steroidal anti-inflammatory drugs (NSAIDs) particularly in prolonged therapy and large doses. We present the management and reviewed the literature. Sixty-two year old man with, vomiting and hiccups of one week after seven weeks of daily Diclofenac sodium100mg and Meloxicam 15 mg, for body pains. Results: He had asterixis. Laboratories showed pyuria, haematuria, anemia (28%), creatinine (714 µmol/L) and potassium (6.9 mmol/L). Histology showed acute interstitial nephritis. He had cardio-protective-treatment and haemodialysis, with kidney function restoration. Conclusion: NSAIDs should be taken in low, single doses and, for short period to avoid AIN. Haemodialysis is beneficial in restoring kidney function.
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