Correlation between In-vitro and In-vivo Studies based on Pharmacokinetic Considerations |Biomedgrid
Journal: American Journal of Biomedical Science & Research (Vol.8, No. 1)Publication Date: 2020-03-09
Authors : Aharon Ronnie Levy; Perri Rozenberg Hasson;
Page : 48-50
Keywords : Clearance; Volume of Distribution; Half-Life; Cytotoxic; Bioavailability;
Abstract
Whenever in-vitro experiments precede the in-vivo studies of a new drug, an effort is being made to transform the generated data into parameters (mainly dosing regimen) that can optimize the in-life stage and reduce the number of animals that might be required. The present manuscript suggests a method for such a transformation, using general pharmacokinetic principles and, if required, assisted by data from the literature.
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