Correlation between In-vitro and In-vivo Studies based on Pharmacokinetic Considerations |Biomedgrid

Whenever in-vitro experiments precede the in-vivo studies of a new drug, an effort is being made to transform the generated data into parameters (mainly dosing regimen) that can optimize the in-life stage and reduce the number of animals that might be required. The present manuscript suggests a method for such a transformation, using general pharmacokinetic principles and, if required, assisted by data from the literature.