IN VITRO ANTILEUKEMIC ACTIVITY OF EUPHORBIA ECHINUS EXTRACT
Journal: Biotechnologia Acta (Vol.15, No. 6)Publication Date: 2022-12-30
Authors : Houda Sbayou Hazal Gür Fatih Özen Fatma Buşra Işik Souad Amghar Abdellatif Elharti Muhsin Konuk Belkis Atasever Arslan;
Page : 70-74
Keywords : Euphorbia echinus; cancer; K562 cells; HL60 cells.;
Abstract
Aim. Cancer continues to pose a serious threat to human health. Euphorbia plants are rich in phenolics, aromatic esters, steroids and several bioactive compounds. Studies have shown the presence of a large number of bioactive compounds in E. echinus including flavonoids, phenolics, and proanthocyanins. Method. There it was investigated cytotoxic effects of E. echinus methanolic extract on K562, HL60, Ishikawa, Raji and SH-SY5Y cells. Results. The E. echinus extract was found to be highly cytotoxic against HL60 and K562 (79.78 and 76.44% cytotoxicity, respectively). DNA fragmentation was exclusively observed in K562 cells indicating that the reduction of viable cells following treatment with E. echinus extract is due to apoptosis. Conclusions. Our results suggest that E. echinus extract might have a drug potential against leukemic cells.
Other Latest Articles
- STANDARDIZATION OF THE PROTEIN CALIBRATORS ISOLATION METHODOLOGY FOR THROMBOPHILIA MARKERS DETECTING IMMUNODIAGNOSTIC TEST SYSTEMS
- THE EXPRESSION OF TLR4, IFN-γ, TGF-β AND TNF-αLL LINE OF HUMAN SMALL CELL LUNG CARCINOMA NCI-H69 AND IN CISPLATIN-RESISTANT SUBLINE NCI-H69/CPR
- STRUCTURAL AND FUNCTIONAL INTERDEPENDENCES OF BIOLOGICAL ORGANISMS IN EXTREME CONDITIONS
- BIOSURFACTANTS: STRUCTURE, FUNCTIONS AND PRODUCTIONS
- MULTIFUNCTIONAL NANOSYSTEMS BASED ON TWO FLUORESCENT DYES, DOXORUBICIN AND CURCUMIN
Last modified: 2023-06-06 01:08:42