Can Glucose-Insulin-Potassium Prevent Skeletal Muscle Ischemia-Reperfusion Injury? |Biomedgrid

Extremity injuries cost an estimated $80 billion a year [1] and exsanguination is a key factor in fatalities following both civilian and military trauma [2,3]. Tourniquets, the primary prevention against extremity exsanguination, and an often used tool in emergent and elective surgeries, are not benign [4]-skeletal muscle apoptosis and necrosis following tourniquet use are common and can lead to limb paralysis, amputation, and even death if rhabdomyolysis and kidney failure occur [5-7]. While muscle does not respond well to ischemia, reperfusion is what causes the most significant damage following tourniquet use in what has been termed the ischemiareperfusion injury [8,9].