The Effect of Otoprotective Substances Against Cisplatin Exposure: A Literature Review |Biomedgrid

Introduction: Progressive and irreversible hearing loss is the most frequent side effect in patients using platinum therapy for head and neck malignancies. Previous studies on cisplatin-induced ototoxicity have shown that accumulation of reactive oxygen species leads to oxidative stress and subsequent intracellular reactions, eventually leading to cell-death. The aim of this study is to review recent evidence about the use of different substances and their otoprotective effect in humans or animals exposed to cisplatin therapy.